ISO 20776-1 PDF

ISO. First edition. Clinical laboratory testing and in vitro diagnostic test systems — Susceptibility testing of infectious agents and evaluation. Buy ISO , Susceptibility testing of infectious agents and evaluation of performance of antimicrobial susceptibility test devices, Part 1, at CLSI. ISO () Clinical laboratory testing and in vitro diagnostic test systems – Susceptibility testing of infectious agents and evaluation of performance of.

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Simultaneous quantification of voriconazole and posaconazole in human plasma by high-performance liquid 207761 with ultra-violet detection. It is generally accepted that broth MIC tests are reproducible to within one doubling dilution of the real end point i.

MIC methods are used in resistance surveillance, comparative testing of new agents, to establish the susceptibility of organisms that give equivocal results in routine tests, for tests on organisms where routine tests may be unreliable and when a quantitative result is required for clinical management. Sitemap Search close sitemap.

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Learn more about the cookies we use and how to change your settings. All these methods are based on those described by Ericsson and Sherris. This article has been cited by other articles in PMC. Prevalidation statistical design to assess analytical methods.

Selective high-performance liquid chromatographic assay ios itraconazole and hydroxyitraconazole in plasma from human immunodeficiency virus-infected patients. It is advisable to compare other susceptibility testing methods e. Author information Article notes Copyright and License information Disclaimer. We use cookies to make our website easier to use and to better understand your needs. Broth microdilution denotes the performance of the broth dilution test in microdilution trays.


Abstract A multicenter study was conducted to assess the accuracy of the ISO kso and the serial 2-fold dilution procedures for antifungal susceptibility testing. Broth dilution is a technique in which containers holding identical volumes of broth with antimicrobial agent solutions in incrementally usually geometrically increasing concentrations are inoculated with a known number of microorganisms.

ISO documents of relevance to antimicrobial susceptibility testing These documents are available for purchase from ISO or national standards organisations. Trays were done in duplicate on separate days at each center and then shipped frozen by special delivery to Spain for 20776–1 chromatographic concentration determinations. Please review our privacy policy. Furthermore, previous 207776-1 have demonstrated a much higher interlaboratory variation in MIC results for quality control strains for itraconazole than for flucytosine and fluconazole 6 – 8.

Thus, ITC data obtained from trays prepared by the Inn Austria participant were excluded from the analysis since tray wrappings showed evidence of defrosting and spillage; also, concentrations of dilutions prepared in Denmark 2077-1 unacceptably different from the target concentrations. Accept and continue Learn more about the cookies we use and how to change your settings.

However, itraconazole trays showed a significant lack of reproducibility that was independent of which method was followed.

Relevant external documents

Itraconazole formulation studies of the melt-extrusion process with mixture design. Precision of itraconazole dilution series by procedure and laboratory a.

Reference method for testing the in vitro activity of antimicrobial agents against rapidly growing anaerobic bacteria involved in infectious diseases. ITC is a 207776-1 basic drug pKa ca. Rapid AST in bloodcultures Previous versions of documents Veterinary Susceptibility Testing Search all products by. You may find similar items within these categories by selecting from the choices below:. Please download Chrome or Firefox or view our browser tips.

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Dilution procedures are used to determine the minimum inhibitory concentrations MICs of antimicrobial agents and are the reference method for antimicrobial susceptibility testing. International Organization for Standards.

EUCAST: External documents

The method described in this part of ISO is intended for the testing of pure cultures of aerobic bacteria that are easily grown by overnight incubation on agar and grow well in Mueller-Hinton broth, which may be supplemented. Sensitive determination of itraconazole and its active metabolite in human plasma by column-switching high-performance liquid chromatography with ultraviolet detection. The broth microdilution method described in this part of ISO is essentially the same as those used in many countries, including France, Germany, Sweden, the United Kingdom, and the United States.

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BS EN ISO 20776-1:2006

Clinical breakpoints for antimycobacterial agents Susceptibility testing of moulds In order to determine and compare the accuracy of isi method described for microdilution, two consecutive HPLC determinations of the azole concentration were calculated from different wells of trays prepared according ISO recommendations, serial dilutions for hydrophobic drugs, and serial dilutions for hydrophilic compounds.

Development and validation of an efficient HPLC method for quantification of voriconazole in plasma and microdialysate reflecting an important target site. National Center for Biotechnology Information20776. The faster, easier way to work with standards. Contact Sitemap Privacy Statement Disclaimer. Calibration and validation – archive